UCM05

UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections^[1][2][3]. In Vitro:UCM05 (5 μM; 24 h) reduces HSV-2 replication in D407 cells by targeting host fatty acid synthesis^[1].
UCM05 binds to Bacillus subtilis FtsZ monomers with micromolar affinity, disrupts normal FtsZ assembly, and weakly inhibits FtsZ GTPase activity by 20%^[3].
UCM05 inhibits cell division in Bacillus subtilis by inducing filamentation and disrupting normal FtsZ-GFP ring formation into punctuate foci and distorted structures^[3]. In Vivo:UCM05 (15-30 mg/kg/d; i.p.; daily; 6 days) administered at 30 mg/kg/d fully protects HSV-2-infected BALB/c mice from mortality, reduces viral replication in vaginal tissues and mitigates vaginal injury and inflammation^[1].