(R)-(-)-N-Boc-3-pyrrolidinol
CAS No. : 109431-87-0
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| Cat. No. : | HY-W001294 |
| M.Wt: | 187.24 |
| Formula: | C9H17NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia[1][2][3].
In Vitro:(R)-(-)-N-Boc-3-pyrrolidinol (9.3-10.3 M) undergoes SN2 alkylation with phenolic nucleophiles under Mitsunobu reaction conditions to construct the corresponding (3S)-aryloxypyrrolidine derivatives in nearly quantitative, moderate, and low yields, respectively[2].
(R)-(-)-N-Boc-3-pyrrolidinol (4.5-7 mM; 3-37 h) is produced by gelatin microsphere-immobilized Sphingomonas sp. HXN-200 cells using N-Boc-pyrrolidine as the substrate, and its production efficiency is higher than that of free suspended cells[3].
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