Ethopropazine (hydrochloride)

Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease^{[1][2][3][4][5]}. IC50 & Target:BChE, AChE^[2] In Vitro:Ethopropazine (0-250 µM, 24 h) hydrochloride exhibits dose-dependent toxicity in LAN-5 cells with an LD₅₀ of 28 µM^[1].
Ethopropazine (<28 µM, 24 h) hydrochloride exhibits proliferative properties in SK-N-SH cells by enhancing [³H] thymidine uptake^[1].
Ethopropazine (10 μM, 24 h) hydrochloride significantly enhances the proliferation of NCI-H69 cells, and this proliferative effect is significantly inhibited by the mAChR3 antagonist 4-DAMP (HY-100958)^[2].
In Vivo:Ethopropazine (10-30 mg/kg, subcutaneous administration, single dose) hydrochloride can alleviate neuropathic pain in rats in a dose-dependent manner, and combination with α₂ agonists can enhance analgesic efficacy while maintaining safety^[3].