SRT 2104
CAS No. : 1093403-33-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $715 | In-stock |
| 200mg | $1155 | In-stock |
| 500mg | $2145 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-15262 |
| M.Wt: | 516.64 |
| Formula: | C26H24N6O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].
IC50 & Target:SIRT1[1]
In Vivo:SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice[2].
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice[2].
SRT 2104 (0.5% in diet; p.o.; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice[3].
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