AD57
CAS No. : 1093380-42-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $900 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-18507 |
| M.Wt: | 455.44 |
| Formula: | C22H20F3N7O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1].
In Vitro: AD57 (0.2 nM) significantly inhibits the ptc?>?dRetMEN2B lethality in the larva of Drosophila[1].
AD57 (0.1 nM) enhances survival of ptc?>?dRetMEN2B by reducing erk gene dosage in Drosophila[1].
In Vivo: AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RETMEN2 models[1].
AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model[1].
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