PLpro inhibitor


CAS No. : 1093070-14-4

1093070-14-4
Price and Availability of CAS No. : 1093070-14-4
Size Price Stock
1mg $85 In-stock
5mg $210 In-stock
10mg $340 In-stock
50mg $980 In-stock
100mg $1350 In-stock
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Cat. No. : HY-17542
M.Wt: 346.42
Formula: C22H22N2O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1093070-14-4 :

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM[1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM[2]. IC50 & Target: IC50 : 2.6 µM (Papain-like protease (PLpro))[1]; 5.0 µM (SARS-CoV-2 PLpro)[2]
EC50: 21.0 µM (SARS-CoV-2 PLpro)[2] In Vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells[1][3].

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