PP487
CAS No. : 1092787-12-6
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| Cat. No. : | HY-15268 |
| M.Wt: | 348.20 |
| Formula: | C14H14BrN5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used for cancer research[1].
IC50 & Target:IC50: 0.017 μM (DNA-PK)[1].
IC50: 0.072 μM (mTOR)[1].
IC50: 0.004 μM (Hck)[1].
IC50: 0.01 μM (Src)[1].
IC50: 1.9 μM (Src (T338I))[1].
IC50: 0.55 μM (EGFR)[1].
IC50: 0.22 μM (EphB4)[1].
IC50: ＜ 0.01 μM (PDGFR)[1].
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