Farnesyl thiosalicylic acid amide
CAS No. : 1092521-74-8
(Synonyms: FTS amide; Salirasib amide)
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| Cat. No. : | HY-112666 |
| M.Wt: | 357.55 |
| Formula: | C22H31NOS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer[1].
In Vitro:Farnesyl thiosalicylic acid amide (50 μM, 24 h) decreases the levels of total Ras-GTP and K-Ras-GTP in Panc-1 and U87 cells[1].
In Vivo:Farnesyl thiosalicylic acid amide (100 mg/kg, i.g., once time) inhibits tumor growth in Panc-1 nude mouse model[1].
Farnesyl thiosalicylic acid amide (100 mg/kg, p.o., twice a day, 14 days) inhibits tumor growth in U87 nude mouse model[1].
Pharmacokinetic Analysis in Panc-1 Nude Mouse Model[1]
| Route | Dose (mg/kg) | half-life (min) | Tmax (h) | Cmax (ng/mL) | AUC0-inf (min*ng/mL) |
| i.g. | 100 | 314 | 110 | 371 | 108783 |