GW 833972A
CAS No. : 1092502-33-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $335 | In-stock |
| 25mg | $690 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-101765 |
| M.Wt: | 444.24 |
| Formula: | C18H14Cl2F3N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GW 833972A is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough[1]. In Vitro:GW 833972A (0.3-300 μM; 10 min) inhibits capsaicin-induced depolarization in humans and guinea pigs, and also inhibits prostaglandin E(2) and hypertonic saline induced depolarization of isolated vagus nerve in guinea pigs[1]. In Vivo:GW 833972A (30 mg/kg, 2 mL/kg; i.p.; single dose 30 min before test) inhibits tussive response in conscious guinea pigs induced by citric acid. It also inhibits capsaicin-induced plasma protein exudation in the main bronchus[1].
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