AZD-8529
CAS No. : 1092453-15-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107457 |
| M.Wt: | 487.47 |
| Formula: | C24H24F3N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
IC50 & Target: EC50: 285 nM (mGluR2)[1]
In Vitro: AZD-8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM[1].
AZD-8529 does not elicit antagonist responses on mGluRs at 25 μM[1].
In Vivo: AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys[1].
AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].
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