Filorexant
CAS No. : 1088991-73-4
(Synonyms: MK-6096)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $428 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $880 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15653 |
| M.Wt: | 420.48 |
| Formula: | C24H25FN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding). IC50 & Target: Ki: < 3 nM(Orexin receptor)[1]. In Vitro: In radioligand binding and functional cell based assays Filorexant (MK-6096) demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Filorexant (MK-6096) occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. In Vivo: Filorexant (MK-6096) dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
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