Taccalonolide A
CAS No. : 108885-68-3
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|---|---|---|
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| 10mg | $250 | In-stock |
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| Cat. No. : | HY-N2416 |
| M.Wt: | 702.74 |
| Formula: | C36H46O14 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3]. IC50 & Target: microtubule[1]
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