Dendrophenol

Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin^[1][2][3][4]. IC50 & Target:NF-κB^[1] In Vitro:Dendrophenol (5-100 μM; 1 h) inhibits the expression of COX-2, iNOS, HIF-1α and NF-κB and inhibits cell activation in LPS (HY-D1056) treated macrophages^[1].
Dendrophenol (0-50 μM; 15 h-6 days) exerts potent cytotoxic effect against tumor cell lines from placenta, lung and stomach, and can cause cell G2 phase arrest^[2].
Dendrophenol (1 μM; 4 days) reduces calcium deposition via the WNT3/β-catenin pathway and reduces calcification induced inflammation by IL13RA2 and STAT3 in Phosphate-treated human aortic smooth muscle cells^[3].
Dendrophenol (3-30 μM; 24 h) induces apoptosis of human colon cancer cell HCT-116 by tubulin depolymerization, DNA damage stress and JNK signaling pathway^[4]. In Vivo:Dendrophenol (10 mg/kg; intraperitoneal injection; 3 weeks) has a beneficial effect in the mouse model of vascular calcification^[3].
Dendrophenol (50-100 mg/kg; intraperitoneal injection; 5 times a week for 2 weeks) has antitumor effect in mouse tumor model^[4].