NIP 502
CAS No. : 108616-42-8
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| Cat. No. : | HY-105400 |
| M.Wt: | 309.75 |
| Formula: | C14H16ClN3O3 |
| Purity: | >98 % |
| Solubility: |
NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma[1].
In Vitro:NIP 502 (30-300 μM, 5 mins) significantly inhibits FMLP (HY-P0224)-induced superoxide anion production by guinea pig alveolar macrophages[1].
In Vivo:NIP-502 (3-10 mg/kg, p.o., 1 h before antigen challenge) inhibits the antigen-induced immediate asthmatic response in passively sensitized guinea pigs[1].
NIP-502 (30 mg/kg, p.o., 1 h before each ovalbumin aerosol inhalation) inhibits the Ovalbumin (HY-W250978)-induced increase in the number of macrophages, eosinophils, and neutrophils in the bronchoalveolar lavage fluid of guinea pigs[1].
NIP-502 (30-50 mg/kg, p.o., 1 h before antigen challenge) inhibits the passive cutaneous anaphylactic reaction in rats[1].
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