Mizolastine
CAS No. : 108612-45-9
| Size | Price | Stock |
|---|---|---|
| 25mg | $30 | In-stock |
| 50mg | $50 | In-stock |
| 100mg | $80 | In-stock |
| 500mg | $140 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B0164 |
| M.Wt: | 432.49 |
| Formula: | C24H25FN6O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial[1][2][3].
In Vitro: Mizolastine (1-10000 nM; 0.5-6 h) shows inhibitory effects on VEGF, KC and TNF-α release in mast cells[1].
Mizolastine (0.1 µM; 4 h) significantly reduces VEGF165, VEGF120, TNF-α and KC mRNA expression in mast cells[1].
In Vivo: Mizolastine (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model[2].
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