Lumichrome
CAS No. : 1086-80-2
| Size | Price | Stock |
|---|---|---|
| 1g | $50 | In-stock |
| 5g | $249 | In-stock |
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| Cat. No. : | HY-115385 |
| M.Wt: | 242.24 |
| Formula: | C12H10N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway[1][2].
In Vitro:Lumichrome (0-100 μM, 24 h) exhibits cytotoxicity in cancer cells H292, A549 and H460 (IC50 = 38, 54 and 79 μM, respectively), induces apoptosis in these cells, and inhibits the colony formation[2].
Lumichrome (0-10 μM, 5-28 days) inhibits RANKL-induced osteoclastogenesis and bone resorption through inhibition of NFAT/NF-κB/MAPK/calcium signaling pathways[3].
In Vivo:Lumichrome (7.5 mg/kg, ip, three times a week for 6 weeks) reduces bone loss and prevents osteoporosis in the ovariectomized (OVX) mouse model[3].
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