AC-93253
CAS No. : 108527-83-9
| Size | Price | Stock |
|---|---|---|
| 10mg | $391 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-118343 |
| M.Wt: | 488.43 |
| Formula: | C23H25IN2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].
IC50 & Target:IC50: 45.3 μM (SIRT1); 6 μM (SIRT2); 24.6 μM (SIRT3)[1].
In Vitro:AC93253 can inhibit SIRT1, SIRT2 and SIRT3 with IC50 values of 45.3 μM, 6 μM and 24.6 μM, respectively[1].
AC-93253 (0, 2, 5, 10 μM; 16 h) significantly enhanced the acetylation of tubulin, p53, and histone H4[1].
AC-93253 exhibits selective cytotoxicity towards four tumor cell lines in a single agent with IC50 values ranging from 10 to 100 nM[1].
AC-93253 significantly triggered apoptosis [1].
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