Ubiquitin Isopeptidase Inhibitor I, G5
CAS No. : 108477-18-5
(Synonyms: NSC144303)
| Size | Price | Stock |
|---|---|---|
| 5mg | $92 | In-stock |
| 10mg | $158 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $500 | In-stock |
| 100mg | $800 | In-stock |
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| Cat. No. : | HY-100738 |
| M.Wt: | 414.39 |
| Formula: | C19H14N2O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (120.66 mM; Need ultrasonic); THF : 3.44 mg/mL (8.30 mM; Need ultrasonic); Ethanol : < 1 mg/mL (ultrasonic) (insoluble); Acetone : 2.86 mg/mL (6.90 mM; Need ultrasonic) |
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. IC50 & Target: IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)[1] In Vitro: G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively[1].
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