Ganoderic acid D
CAS No. : 108340-60-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $130 | In-stock |
| 10mg | $215 | In-stock |
| 25mg | $450 | In-stock |
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| Cat. No. : | HY-N1511 |
| M.Wt: | 514.65 |
| Formula: | C30H42O7 |
| Purity: | >98 % |
| Solubility: | H2O : 0.1 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].
In Vitro: Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].
Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner[2].
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest[2].
Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells[2].
Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3[2].
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