Temafloxacin


CAS No. : 108319-06-8

(Synonyms: TMFX; TA-167 (free acid); A-62254 (free acid))

108319-06-8
Price and Availability of CAS No. : 108319-06-8
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5mg $100 In-stock
10mg $160 In-stock
25mg $280 In-stock
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Cat. No. : HY-16487
M.Wt: 417.38
Formula: C21H18F3N3O3
Purity: >98 %
Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 108319-06-8 :

Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections[1][2]. In Vitro: Temafloxacin (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1]. In Vivo: Temafloxacin (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].

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