N-Acetyl-Calicheamicin
CAS No. : 108212-76-6
(Synonyms: N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin)
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| Cat. No. : | HY-19791 |
| M.Wt: | 1410.39 |
| Formula: | C57H76IN3O22S4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].
In Vitro:N-Acetyl-Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]
Once the ADC is internalized and degraded in the lysosome, the potent calicheamicin derivative, N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), is then activated by reduction of the dimethyl disulfide trigger in the cytosol to form the potent enediyne diradical capable of inducing DNA strand breaks[2]
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