KT5720
CAS No. : 108068-98-0
| Size | Price | Stock |
|---|---|---|
| 50μg | $170 | Get quote |
| 100μg | $286 | Get quote |
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| Cat. No. : | HY-N6789 |
| M.Wt: | 537.61 |
| Formula: | C32H31N3O5 |
| Purity: | >98 % |
| Solubility: | Methanol : 5 mg/mL (ultrasonic;warming) |
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC50=3.3 µM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2+ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases[1][2][3].
IC50 & Target:IC50: 11 nM (PHK); 300 nM (PDK1); 3.3 µM (PKA)[3].
In Vitro:KT5720 (0-8 µM; 72 h) reverses multidrug resistance in an MDR1 lymphoma cell model[1].
KT5720 (3 µM) attenuates Ih in freshly isolated rat DRG neurons and slows down HCN channel activation kinetics[2].
KT5720 (3 µM) reduces DRG neurons excitability and reduces DRG neuron intracellular Ca2 + level[2].
In Vivo:KT5720 (5 mg/kg; i.p.; single daily for 8 days) reverses completely DNR resistance in MDR1 transgenic mice model[1].
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