Roxindole (hydrochloride)
CAS No. : 108050-82-4
(Synonyms: EMD 38362)
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $980 | In-stock |
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| Cat. No. : | HY-106100A |
| M.Wt: | 382.93 |
| Formula: | C23H27ClN2O |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 50 mg/mL (ultrasonic) |
Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].
In Vivo: Roxindole hydrochloride inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1].
Roxindole hydrochloride (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3].
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