Tilmicosin
CAS No. : 108050-54-0
(Synonyms: LY-177370; EL-870)
| Size | Price | Stock |
|---|---|---|
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| 500mg | $60 | In-stock |
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| Cat. No. : | HY-B0905 |
| M.Wt: | 869.13 |
| Formula: | C46H80N2O13 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);1M HCl : 100 mg/mL (ultrasonic;adjust pH to 1 with HCl) |
Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects[1][2][3][4][5][6].
In Vitro:Tilmicosin (0-7 μg/mL; 16-18 h) has the MIC for 90% of Staphylococcus aureus isolates from the bovine udder of 0.78 μg/mL[1].
Tilmicosin (0.5μg /mL; 2 h) induces apoptosis of bovine neutrophils[2].
Tilmicosin (5-20 μg/mL; 18 h) inhibits the expression of COX-2 and iNOS in LPS (HY-D1056) treated macrophages, and affects the secretion of cytokines[3].
In Vivo:Tilmicosin (75 mg/kg; subcutaneous injection; single dose) induces cardiotoxicity in mice[4].
Pharmacokinetic Analysis in lung tissues of the M. gallisepticum infected chickens[5]
| Route | Dose (mg/kg) | t1/2kel (h) | Tmax (h) | Cmax (μg/g) | AUC (μg·h/g) | MRT (h) | CL/F (1/h/kg) |
| p.o. | 1 | 48.46 | 12.00 | 0.12 | 13.62 | 53.60 | 0.09 |
| p.o. | 30 | 50.60 | 12.00 | 6.19 | 464.23 | 50.88 | 0.06 |