Melamine
CAS No. : 108-78-1
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|---|---|---|
| 25g | $10 | In-stock |
| 100g | $19 | In-stock |
| 500g | $27 | In-stock |
| 1000g | $53 | In-stock |
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| Cat. No. : | HY-Y1117 |
| M.Wt: | 126.12 |
| Formula: | C3H6N6 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 1 mg/mL (ultrasonic) |
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models[1][2][3][4][5][6].
In Vitro: Melamine (0-1000 g/mL, 24 h) suppresses cell viability and induces cell apoptosis in concentration-dependent manner in Sertoli cells[1].
Melamine (50 g/mL, 24 h) down-regulates the expressions of junction-associated proteins including occludin, N-cadherin, and vimentin, suggesting that MA disrupts the integrity of Sertoli cell barrier[1].
In Vivo: Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Melamine (300 mg/kg, p.o., daily, 28 days) is able to impair the learning and memory abilities and reduces rats weight [2].
Melamine (60-600 mg/kg, p.o., daily, 2 weeks) impairs endothelial function and increases pro-inflammatory and pro-fibrotic markers in renal arteries of rats dose-dependently[3].
PK parameter of Melamine. The half-life (t1/2) is 32.2-32.9 hours, the clearance (Clz/F) is 35.9-36.6 mL/h/kg, and the volume of distribution (Vss) is 1.67-1.74 L/kg[8].
Melamine can be used in animal modeling to construct models of acute nephrotoxicity, cognitive deficits, and urinary stone formation[5][6][7].
Administration: 100, 300, 600 mg/kg • p.o. • 15 days
Phenotypic observations: Increases kidney weight, crystal deposition in the renal papillary collecting ducts, and renal inflammation were observed.
Administration: 300 mg/kg • p.o. • daily for 4 weeks.
Behavioral observation: Induces symptoms of piloerection and haematuria as well as reduced spontaneous activity.
Administration: 1 and 3% Melamine • p.o. • daily for 40 weeks.
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