Dimethyl malonate


CAS No. : 108-59-8

108-59-8
Price and Availability of CAS No. : 108-59-8
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500g $27 In-stock
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Cat. No. : HY-Y1787
M.Wt: 132.11
Formula: C5H8O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic)
Introduction of 108-59-8 :

Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. In Vivo: Dimethyl malonate (6 mg/kg/min; intravenous infusion; 51 min) promotes return of spontaneous circulation (ROSC) and neurological performance in rats after cardiac arrest[1].

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