LY 178002
CAS No. : 107889-32-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $138 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101579 |
| M.Wt: | 319.46 |
| Formula: | C18H25NO2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase. IC50 & Target: Ki: 0.6 μM (5-lipoxygenase)[1] In Vitro: LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1]. In Vivo: LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].
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