AA 193

AA 193 is an orally active uricosuric agent. AA 193 inhibits the net reabsorption of uric acid in nephrons, regulates the renal reabsorption process of filtered uric acid, promotes uric acid excretion in a dose-dependent manner, and reduces serum uric acid levels. AA 193 mildly inhibits the activity of xanthine dehydrogenase (XDH). AA 193 can be used in studies related to hyperuricemia^[1][2]. In Vitro:AA 193 (1 mM; 20 min) has no effect on uricase activity in the lysosomal fraction of rat liver homogenate^[1].
AA 193 (0.2-1 mM; 20 min) shows no effect on xanthine dehydrogenase activity in the cytosolic fraction of rat liver homogenate at a concentration of 0.2 mM, while 1 mM AA-193 slightly inhibits the activity of this enzyme^[1]. In Vivo:AA-193 (20-100 mg/kg; p.o.; once daily; for 7 consecutive days) maintains dose-dependent uricosuric activity without altering plasma uric acid levels after 7 consecutive days of daily oral administration in normal rats^[1].
AA-193 (20-100 mg/kg; p.o.; once daily; for 7 consecutive days) exerts dose-dependent urate-lowering activity in hyperuricemic rats^[1].