Garcinone D
CAS No. : 107390-08-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $270 | In-stock |
| 10mg | $435 | In-stock |
| 25mg | $870 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-N6953 |
| M.Wt: | 428.47 |
| Formula: | C24H28O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2].
In Vitro:Garcinone D (5-400 μM; 24 h) regulates the cell viability of C17.2 neural stem cells. And increases cell viability at 5-10 μM, while significantly reduces cell viability at 20-40 μM[1].
Garcinone D (5 μM; 24 h) promotes the transition of C17.2 neural stem cells in the G1-S phase and arrests the cell cycle in the S phase[1].
Garcinone D (3-10 μM; 6-24 h) increases the levels of p-STAT3, Cyclin D1, Nrf2 and HO-1 proteins in C17.2 neural stem cells in a concentration- and time-dependent manner[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Garcinone D
- Cat. No.:
- HY-N6953
- Quantity:
Your information is safe with us.