TD-0212
CAS No. : 1073549-10-6
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| Cat. No. : | HY-114412 |
| M.Wt: | 527.65 |
| Formula: | C28H34FN3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
IC50 & Target: pKi: 8.9 (AT1)
pIC50: 9.2 (NEP)[1].
In Vitro: TD-0212 (compound 35) provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition[1].
In Vivo: TD-0212 (compound 35) produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and –independent hypertension[1].
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