FKGK18
CAS No. : 1071001-09-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $480 | In-stock |
| 10mg | $768 | In-stock |
| 25mg | $1536 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-115403 |
| M.Wt: | 280.28 |
| Formula: | C16H15F3O |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming) |
FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes[1][2][3]. IC50 & Target:IC50: 50 nM (iPLA2β), 3 μM (iPLA2γ)[2] In Vitro:FKGK18 (1 nM; 1 h) inhibits glucose-stimulated insulin secretion (GSIS) and prostaglandin E2 (PGE2) generation[2]. FKGK18 (0.1-10 nM; 24 h) inhibits beta-cell apoptosis[3]. FKGK18 (0.1-10 μM; 24 h) affects immune cells function and influences B-cell survival[3]. In Vivo:FKGK18 (20 mg/kg; i.p. three times per week from 10 days until euthanasia) reduces diabetes incidence[3].
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