FKGK11
CAS No. : 1071000-98-0
| Size | Price | Stock |
|---|---|---|
| 17.84mM * 200 μL in Ethanol | $260 | Get quote |
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| Cat. No. : | HY-116018 |
| M.Wt: | 280.23 |
| Formula: | C13H13F5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].
IC50 & Target:GVIA iPLA2[1]
In Vitro:FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction[1].
FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells[2].
In Vivo:FKGK11 inhibits tumor development in the xenograft mouse model[2].
FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA / mice and C57BL/6 mice[3].
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