Flortanidazole

Flortanidazole is a derivative of 2-Nitroimidazole (HY-N0195). Under hypoxic conditions, Flortanidazole accumulates in hypoxic tissues through the reduction of 2-nitroimidazole and the retention of reactive intermediates by viable hypoxic cells. Flortanidazole binds to intracellular macromolecules under hypoxic conditions, thereby enabling quantification of tumor hypoxia. [¹⁸F]Flortanidazole, formed after labeling Flortanidazole with ¹⁸F, is a hypoxic PET imaging tracer and prognostic imaging biomarker. Flortanidazole can be used in the study of non-small cell lung cancer and colorectal cancer^[1][2]. In Vivo:[¹⁸F]flortanidazole (18.5 MBq; intravenous injection) imaging in a histological satellite study shows that Metformin (HY-B0627) treatment for 48 h results in a non-significant decrease in tumor hypoxia detected by Pimonidazole (HY-105129A) (3.48% vs. 10.79% in the control group)^[2].