SCD1 inhibitor-1
CAS No. : 1069094-65-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
| 25mg | $1120 | In-stock |
| 50mg | $1750 | In-stock |
| 100mg | $2500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112812 |
| M.Wt: | 451.54 |
| Formula: | C21H22N3NaO3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity[1].
IC50 & Target:IC50: 8.8 nM (Recombinant human SCD1 enzyme)[1]
In Vivo:SCD1 inhibitor-1 (3-10 mg/kg; oral administration; 43 days) has an improved effect in high-fat mice models[1].
SCD1 inhibitor-1 (1-10 mg/kg; oral administration; single dose) has an improved effect in high-sucrose rat models[1].
Pharmacokinetic Analysis in rat and mouse[1]
| Species | Route | Dose (mg/kg) | Cmax (μM) | tmax (h) | t1/2 (h) | AUC0-inf (μM·h) | BA (%) | Cltot (L/h/kg) |
| Rat | p.o. | 10 | 8.0 | 0.5 | 4.7 | 16.5 | 16 | / |
| Mouse | p.o. | 10 | 1.7 | 1.0 | 5.2 | 10.2 | 28 | / |
| Rat | i.v. | 1 | / | / | / | / | / | 0.21 |
| Mouse | i.v. | 1 | / | / | / | / | / | 0.61 |