Valproic acid (sodium) (Standard)


CAS No. : 1069-66-5

(Synonyms: Sodium Valproate (Standard); VPA (sodium) (Standard); 2-Propylpentanoic acid (sodium) (Standard))

1069-66-5
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Cat. No. : HY-10585AR
M.Wt: 166.19
Formula: C8H15NaO2
Purity: >98 %
Solubility: H2O : 125 mg/mL (752.15 mM; Need ultrasonic)
Introduction of 1069-66-5 :

Valproic acid (sodium) (Standard) is the analytical standard of Valproic acid (sodium). This product is intended for research and analytical applications. Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7]. IC50 & Target:IC50: 400 μM (HDAC1), 0.5-2 mM (HDAC)[5] HDAC2[6]

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