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| Cat. No. : | HY-113678 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].
In Vivo: Colistin (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].
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