Colistin


CAS No. : 1066-17-7

(Synonyms: Polymyxin E)

1066-17-7
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Cat. No. : HY-113678
M.Wt: 1000.00
Formula: N/A
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1066-17-7 :

Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2]. In Vivo: Colistin (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

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