Dafadine-A
CAS No. : 1065506-69-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 50mg | $260 | In-stock |
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| Cat. No. : | HY-16670 |
| M.Wt: | 391.46 |
| Formula: | C23H25N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1). Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s[1].
In Vitro:Dafadine-A (12.5 μM; treating wild-type Caenorhabditis elegans) induces a constitutive dauer formation (Daf-c) phenotype in more than 30% of worms[1].
Dafadine-A (25 μM; treating wild-type Caenorhabditis elegans) causes a protruding vulva (Pvl) phenotype and distal-tip cell migration (Mig) defects in over 60% of worms[1].
Dafadine-A (5 μM) inhibits the ability of CYP27A1 to metabolize 4-cholesten-3-one[1].
Dafadine-A extends the lifespan of wild-type Caenorhabditis elegans by 29%[1].
Dafadine-A (5-10 μM; 48 h) dramatically inhibits cholesterol-induced melanoma spheroid propagation and downregulates Rap1A/Rap1B expression and phosphorylated AKT1-thr308/309[2].
Dafadine-A (10 μM; 48 h) significantly enhances Vemurafenib (HY-12057)-induced apoptosis[2].
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