Sertindole
CAS No. : 106516-24-9
(Synonyms: Lu 23-174)
| Size | Price | Stock |
|---|---|---|
| 5mg | $58 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $225 | In-stock |
| 50mg | $424 | In-stock |
| 100mg | $590 | In-stock |
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| Cat. No. : | HY-14543 |
| M.Wt: | 440.94 |
| Formula: | C24H26ClFN4O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells[1][2][3].
In Vitro:Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells[2].
Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro[2].
Sertindole (5 μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells[2].
In Vivo:Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo[2].
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