PF-4479745
CAS No. : 1065110-43-1
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| Cat. No. : | HY-118339 |
| M.Wt: | 282.38 |
| Formula: | C17H22N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension[1].
In Vitro: PF-4479745 (copmpound 17) exhibits metabolic stability in both human liver microsomes (HLM) and human hepatocytes[1].
In Vivo: PF-4479745 (compound 17, intravenous injection) shows high clearance rate (104 mL/min/kg)[1].
PF-4479745 demonstrates a robust dose-dependent effect in canine PUP (peak urethral pressure) model of SUI (stress urinary incontinence)[1].
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