SNT-207707
CAS No. : 1064662-40-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $117 | In-stock |
| 5mg | $320 | In-stock |
| 10mg | $534 | In-stock |
| 25mg | $1122 | In-stock |
| 50mg | $1740 | In-stock |
| 100mg | $2700 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-11029 |
| M.Wt: | 550.18 |
| Formula: | C32H44ClN5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL |
SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 can cross blood-brain barrier[1][2][3]. IC50 & Target:IC50: 8 nM (binding MC-4), 5 nM (function MC-4)[1] In Vitro:SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1]. In Vivo:Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].
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