Peptide T


CAS No. : 106362-32-7

106362-32-7
Price and Availability of CAS No. : 106362-32-7
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10mg $160 In-stock
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Cat. No. : HY-P0272
M.Wt: 857.86
Formula: C35H55N9O16
Purity: >98 %
Solubility: H2O : 100 mg/mL (ultrasonic)
Introduction of 106362-32-7 :

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. IC50 & Target:CD4, HIV[1] In Vitro:Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3]. In Vivo:Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].

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