NHNB
CAS No. : 106359-61-9
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| Cat. No. : | HY-115442 |
| M.Wt: | 263.29 |
| Formula: | C17H13NO2 |
| Purity: | >98 % |
| Solubility: |
NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection[1][2].
In Vitro:NHNB (Compound 4) inhibits recombinant human HDAC8 with an IC50 of 66.0 μM[1].
NHNB (0-5000 μM; 5 min) acts as a competitive inhibitor of purified B. cereus BC1974 peptidoglycan deacetylase with an IC50 of 43.3 μM and a Ki of 8.7 μM[2].
NHNB (0-5000 μM; 10 min) acts as a competitive inhibitor of purified B. cereus BC1960 peptidoglycan deacetylase with an IC50 of 132 μM and a Ki of 66.0 μM[2].
NHNB (4 μg/mL; 16 h) induces onger chains of daughter cell production in B. cereus and B. anthracis[2].
NHNB shows MICs of 5.26-7.89 μg/mL and MBcs of 8.23 μg/mL for B. cereus ATCC
14,579 and B. anthracis 7702[2].
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