Tin(IV) mesoporphyrin IX (dichloride)

Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia^{[1][2][3][4][5][6][7]}. IC50 & Target:HO^[1] In Vitro:Tin(IV) mesoporphyrin IX dichloride (25 μM; 24 h) does not enhance the inhibitory effect of IFN-β1 on PY8119 cell viability when co-treated with IFN-β1^[4].
Tin(IV) mesoporphyrin IX dichloride (1-20 μM; 3 days) reduces the antiviral effect of Sofalcone (HY-B2184) on dengue virus (DENV)-infected Huh-7 cells, reverses the upregulation of HO-1 and interferon (IFN)-related genes^[5]. In Vivo:Tin(IV) mesoporphyrin IX dichloride (25 μmol/kg; daily) causes tumor growth arrest in perforin-deficient (Prf1^-/-) MMTV-PyMT mice^[4].
Tin(IV) mesoporphyrin IX dichloride (5-10 mg/kg; i.p.; once daily; 4-6 weeks) enhances the bactericidal activity of the SPaO regimen in BALB/c mice with chronic Mycobacterium tuberculosis (Mtb) infection, reduces lung bacterial burden, and does not alter lung pathology^[6].
Tin(IV) mesoporphyrin IX dichloride (25 mg/kg; p.o.; daily) decreases bilirubin levels in 66Cl-4 TNBC tumor interstitial fluid in immunocompetent mice, reduces the immunosuppressive ability of tumor-associated macrophages, and does not affect mouse survival^[7].