ML347
CAS No. : 1062368-49-3
(Synonyms: LDN 193719)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $215 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $660 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12274 |
| M.Wt: | 352.39 |
| Formula: | C22H16N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1[1][2]. IC50 & Target: IC50:46 mM; 32 nM; 10800 nM. Target: ALK1; ALK2; ALK3 In Vitro: ML347 can inhibits ALK1/ALK2 to block TGF‑β signal transduction[2].
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