LDN193189
CAS No. : 1062368-24-4
(Synonyms: DM-3189)
| Size | Price | Stock |
|---|---|---|
| 2mg | $50 | In-stock |
| 5mg | $84 | In-stock |
| 10mg | $108 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $425 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12071 |
| M.Wt: | 406.49 |
| Formula: | C25H22N6 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;adjust pH to 4 with HCl);H2O : 5 mg/mL (ultrasonic;warming;adjust pH to 2 with 1 M HCL;heat to 60°C);H2O : < 0.1 mg/mL |
LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].
IC50 & Target:IC50: 5 nM (ALK2), 30 nM (ALK3)[1]
In Vitro:LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively[1].
LDN-193189 has weake effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 with IC50 values of ≥ 500 nM[1].
LDN-193189 binds ActRIIA with Kd value of 14 nM[2].
LDN-193189 (0.5 μM; 30 min) targets GDF8 induced Smad2/3 signaling and repression of myogenic transcription factors[2].
LDN-193189 (0.05, 0.5, 5 μM) efficiently inhibits GDF8 induced Smad3/4 reporter gene activity[2].
LDN-193189 (0-5 μM) rescues myogenesis in myoblasts treated with GDF8[2].
In Vivo:LDN-193189 (i.p.; 3 mg/kg; daily; for 35 days) might affect the interaction between breast cancer cells and the bone environment[3].
LDN-193189 (i.p.; 3 mg/kg; single) shows a reduction in ectopic ossification and functional impairment[1].
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