PND-1186
CAS No. : 1061353-68-1
(Synonyms: VS-4718; SR-2516)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $175 | In-stock |
| 50mg | $269 | In-stock |
| 100mg | $388 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13917 |
| M.Wt: | 501.50 |
| Formula: | C25H26F3N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1].
IC50 & Target: IC50: 1.5 nM (FAK)[1]
In Vitro: PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397[1].
In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 µM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h[1].
In Vivo: PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis[1].
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