Soporidine

Soporidine is an antagonist of germination of the parasitic plant Striga hermonthica. Soporidine specifically inhibits a S. hermonthica strigolactone receptor and inhibits the parasite's germination^[1]. Soporidine is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro: Soporidine binds to the AtHTL receptor and to a key Strigolactone (SL) receptor in S. hermonthica, inhibiting Striga germination in the presence of SLs. Soporidine could serve as the basis for the development of Strigolactone (SL) antagonist to combat Striga infestations. Soporidine is a potent antagonist in GR24-dependent Arabidopsis germination assay and shows no enhancement of SL signaling mutant phenotypes^[1].