1,4-Dichlorobenzene
CAS No. : 106-46-7
Price and Availability of
CAS No. : 106-46-7
| Size | Price | Stock |
|---|---|---|
| 1g | $25 | In-stock |
| 5g | $40 | In-stock |
| 10g | $50 | In-stock |
| 25g | $70 | In-stock |
| 50g | $90 | In-stock |
| 100g | $117 | In-stock |
| 200 g | Get quote | |
| 500 g | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-Y0496 |
| M.Wt: | 147.00 |
| Formula: | C6H4Cl2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Introduction of
106-46-7
:
1,4-Dichlorobenzene (150-300 mg/kg/day; gavage; 5 days per week; two years) induces a dose-related increase in renal tubular cell adenocarcinomas in male F344 rats[1].
1,4-Dichlorobenzene (gavage; daily; 90 days) induces mitogenic liver growth and hepatocellular proliferation in male and female B6C3F1 mice, with liver size returning to normal after compound withdrawal[1].
1,4-Dichlorobenzene (300 ppm; inhalation; continuous; 2 years) increases the incidence of hepatocellular carcinoma and hepatoblastoma in male and female B6C3F1 mice[2].
1,4-Dichlorobenzene (1800 mg/kg; i.g.; single dose) induces a 4.5-fold elevation in serum ALT levels in male B6C3F1 mice[2].
1,4-Dichlorobenzene (300 mg/kg; p.o.; daily; 2 years) induces renal tubular adenocarcinoma and mononuclear cell leukemia in male F344 rats[2].
1,4-Dichlorobenzene (600 ppm; inhalation; continuous; 13 weeks) increases the frequency of elevated serum ALT levels in male and female BDF1 mice[2].
1,4-Dichlorobenzene (inhalation) induces hepatic cell proliferation in male and female B6C3F1 mice[2].
1,4-Dichlorobenzene is a non-genotoxic, orally active mitogenic/tumor-promoting carcinogen that is also widely used as a dye, resin intermediate, and deodorant, moth repellent/insecticide. 1,4-Dichlorobenzene induces liver tumors in mice and promotes the growth of spontaneous precancerous lesions, but shows no liver tumor-inducing activity in F344 rats. 1,4-Dichlorobenzene increases the levels of white blood cell count, serum alanine aminotransferase and blood urea nitrogen in occupationally exposed populations. 1,4-Dichlorobenzene is metabolized to 2,5-dichlorophenol and excreted in urine, and this metabolite can serve as a biomarker for 1,4-Dichlorobenzene exposure. Due to its specific hepatotoxic characteristics, 1,4-Dichlorobenzene is applicable to liver cancer-related research[1][2].
In Vitro:1,4-dichlorobenzene undergoes hepatic cytochrome P450-mediated biotransformation with distinct profiles across male Wistar rats, male F344 rats, male B6C3F1 mice, and female B6C3F1 mice[2].
In Vivo:1,4-Dichlorobenzene (300-600 mg/kg/day; gavage; 5 days per week; two years) induces liver tumors (hepatocellular adenomas and carcinomas) and nonneoplastic liver lesions in male and female B6C3F1 mice, with significant tumor increases seen at 600 mg/kg/day in both sexes and 300 mg/kg/day in males[1].1,4-Dichlorobenzene (150-300 mg/kg/day; gavage; 5 days per week; two years) induces a dose-related increase in renal tubular cell adenocarcinomas in male F344 rats[1].
1,4-Dichlorobenzene (gavage; daily; 90 days) induces mitogenic liver growth and hepatocellular proliferation in male and female B6C3F1 mice, with liver size returning to normal after compound withdrawal[1].
1,4-Dichlorobenzene (300 ppm; inhalation; continuous; 2 years) increases the incidence of hepatocellular carcinoma and hepatoblastoma in male and female B6C3F1 mice[2].
1,4-Dichlorobenzene (1800 mg/kg; i.g.; single dose) induces a 4.5-fold elevation in serum ALT levels in male B6C3F1 mice[2].
1,4-Dichlorobenzene (300 mg/kg; p.o.; daily; 2 years) induces renal tubular adenocarcinoma and mononuclear cell leukemia in male F344 rats[2].
1,4-Dichlorobenzene (600 ppm; inhalation; continuous; 13 weeks) increases the frequency of elevated serum ALT levels in male and female BDF1 mice[2].
1,4-Dichlorobenzene (inhalation) induces hepatic cell proliferation in male and female B6C3F1 mice[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- 1,4-Dichlorobenzene
- Cat. No.:
- HY-Y0496
- Quantity:
Your information is safe with us.