Citronellol
CAS No. : 106-22-9
(Synonyms: (±)-Citronellol; (±)-β-Citronellol)
| Size | Price | Stock |
|---|---|---|
| 100g | $22 | In-stock |
| 500g | $36 | In-stock |
| 1000g | $71 | In-stock |
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| Cat. No. : | HY-W010201 |
| M.Wt: | 156.27 |
| Formula: | C10H20O |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 100 mg/mL |
Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis[2][4][6][7]. IC50 & Target:IC50: 54.02，40.64，52.51，45.84，50.1 μg/mL (A549、NCI-H1299、NCI-H23、BT-20、PC3 cells) (Apoptosis)[6]. In Vitro:Citronellol (50, 100 μg/mL, 72 h) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways[2]. Citronellol can be used as a skin contact allergen after forming hydrogen peroxide through self oxidation[3]. Citronellol (0-100 μg/mL, 48 h) can induce necrotic apoptosis in human lung cancer cell line NCI-H1299 through the TNF-α pathway and accumulation of reactive oxygen species[6]. Citronellol (0-100 μg/mL, 48 h) exhibits cytotoxicity towards A549, NCI-H1299, NCI-H23, BT-20, and PC3 cells, with IC50 values of 54.02, 40.64, 52.51, 45.84, and 50.1 μg/mL, respectively[6]. In Vivo:Citronellol (25, 50, 100 mg/kg; once daily; 2 weeks; p.o.) has a cardioprotective effect on the cardiotoxicity of Doxorubicin (HY-15142A) induced myocardial ischemia in rats[1]. Citronellol (25 mg/kg; once daily; 4 weeks; p.o.) can reduce the levels of LC-3 and p62 to regulate autophagy pathway, inhibit oxidative stress and neuroinflammation, thereby exerting neuroprotective effects on Parkinson's rats[4]. Citronellol (50, 100 mg/kg; once daily; 4 days; p.o.) can protect the kidneys in rhabdomyolysis induced acute kidney injury in mice through its anti apoptotic effect[5]. Citronellol (12.5, 25, 50 mg/kg; once daily; 20 days; i.p.) exhibits anti-tumor activity in non-small cell lung cancer mice[6].
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