Hydroxytyrosol

Hydroxytyrosol (DOPET) is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis^{[1][2][3][4][5][6][7][8]}. In Vitro:Hydroxytyrosol inhibits cells proliferation and inhibits LPS (HY-D1056)-induced TNF-a, IL-1b, IL-6 and IL-17 secretion in splenocytes and peritoneal macrophages from SLE mice^[4].
Hydroxytyrosol (100 μg/mL) inhibits Staphylococcus aureus with the highest Zone of inhibition of 30 mm, and Staphylococcus epidermidis of 25 mm^[5].
Hydroxytyrosol shows MIC of 3.125 μg/mL against Staphylococcus aureus^[5].
Hydroxytyrosol (50-200 μg/mL, 24-48 h) inhibits proliferation, decreases mitochondrial membrane potential and induces apoptosis and ROS production in DLD1 cells^[7].
In Vivo:Hydroxytyrosol (20-40 mg/kg, i.g., daily for 10 days) inhibits inflammation and increases survival rate in LPS (HY-D1056)-mediated septic mice^[1].
Hydroxytyrosol (10 mg/kg, p.o., daily for 10 weeks) increases atherosclerotic lesion in Apo E deficient mice with low cholesterol-diet^[2].
Hydroxytyrosol (5 mg/kg, i.g., daily for 6 months) improves cognitive function in APP/PS1 mice^[3].
Hydroxytyrosol (0.4 mg, p.o., daily for 6 months) prevents Pristine (HY-N7819)-induced systemic lupus erythematous (SLE) in mice^[4].
Hydroxytyrosol (1-10 mg/kg, p.o., daily for 2 months) shows neuroprotective effect in diabetic rats^[6].